杨藩
一、基本信息
杨藩,男,汉族,籍贯四川绵阳市,中共党员,理学博士,青年教授,博士生导师。
二、教育及工作经历
教育经历:
2008.09 – 2012.06, 西北农林科技大学,动物科学专业毕业,农学学士(创新基地班,第四年开进入研究生阶段)
2012.09 – 2017.12, 西北农林科技大学,生理学专业毕业,理学博士 (猪多能性细胞维持分子机理研究,合作导师 王华岩)
2015.10 – 2017.12, 美国西奈山医学院,干细胞与发育平台,联合培养博士 (小鼠全能性能细胞转化机制研究,合作导师 Jianlong Wang)
工作经历:
2017年12月至2018年6月,在西奈山医学院从事全职博士后科研工作 (小鼠心脏发育相关基因研究,合作导师 Chenleng Cai)
2018年6月至2020年12月,在印第安纳大学医学院从事全职博士后科研工作 (小鼠心脏发育相关基因研究,合作导师 Chenleng Cai)
2021年1月至今,在西北农林科技大学动物医学院基础兽医系从事教学科研工作,教授。
三、研究方向及开设课程
目前开展小鼠多能性干细胞向全能性细胞转化及心脏流出道发育调控相关研究。
本科生《细胞生物学》或《生理学》课程和研究生《干细胞与组织工程》《动物生物技术专题》课程
四、代表性学术成果
发表论文:
1、代表性论文
(1) Fan Yang, Xin Huang, Ruge Zang, Jiayu Chen, Miguel Fidalgo, Carlos Sanchez-Priego, Jihong Yang, Alexander Caichen, Fanglin Ma, Todd Macfarlan, Huayan Wang, Shaorong Gao*, Hongwei Zhou, Jianlong Wang*, DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State. Cell stem Cell, 2020, 26(2): 234–250
(2) Fan Yang, Yahui Ren, Huan Li, Huayan Wang*, ESRRB plays a crucial role in the promotion of porcine cell reprogramming. Journal of cellular physiology, 2018; 233:1601–1611
(3) Fan Yang, Ning Wang, Yaxian Wang, Tong Yu, Huayan Wang*. Activin‐SMAD signaling is required for maintenance of porcine ips cell self‐renewal through upregulation of nanog and oct4 expression. Journal of cellular physiology, 2017. 232(8): p. 2253-2262
(4) Fan Yang, Xiaomin Du, Yaxian Wang, Chuanzhen Wang, Changcai Huang, Qundeng Xiao, Xue Bai, Huayan Wang*. Characterization and functional analysis of porcine estrogen-related receptors and their alternative splicing variants. Journal of Animal Science, 2015, 93(9):4258-66
(5) Fan Yang, Jinglong Zhang, Yajun Liu, De Cheng, Huayan Wang*. Structure and functional evaluation of porcine NANOG that is a single-exon gene and has two pseudogenes. The international journal of biochemistry & cell biology, 2015, 59: 142–152
2、代表性论文外的学术成果(合计10项以内)。
(1) Fan Yang, Ning Wang, Yajun Liu, Huayan Wang*. Identification and functional analysis of porcine basic helix-loop-helix transcriptional factor 3 (TCF3) and their alternative splicing isoforms. Res. Vet. Sci, 2016,105:1-4
(2) 杨藩, 王亚娴,杜丽霞,王华岩. 猪 ESRRB 启动子克隆及其调控活性检测. 生物工程学报, 2015, 31.004: 491-500.
(3) 杨藩, 王宁, 徐西占, 司玮, 王苗, 王华岩. 转lux基因簇大肠杆菌在小鼠肠道内定植模型的建立. 农业生物技术学报, 2014, 22.8: 925-932.
(4) 王亚娴, 杨藩(共同一作), 王华岩. Sall4 表达调控及其启动子核心调控区的筛选. 中国农业科学, 2016, 49.1: 176-185.
(5) Donghua Hu, Lu Zhang, Fan Yang, Fuxue Chen, Deqiang Li, Chen-Leng Cai. Generation of Pecam1 endothelial specific dual reporter mouse model. genesis, 2020, 58.9: e23384.
(6) Jian Ruan, Lu Zhang, Donghua Hu, Xianghu Qu, Fan Yang, Fuxue Chen, Xiangqin He, Jian Shen, Kunzhe Dong, Megan Sweet, Christina Sanchez, Deqiang Li, Weinian Shou, Jiliang Zhou*, Chen-Leng Cai*. Novel Myh11 Dual Reporter Mouse Model Provides Definitive Labeling and Identification of Smooth Muscle Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ATVBAHA. 120.315107.
(7) Lu Zhang, Nishat Sultana, Jianyun Yan, Fan Yang, Fuxue Chen, Elena Chepurko, Feng-Chun Yang, Qinghua Du, Lior Zangi, Mingjiang Xu, Lei Bu, Chen-Leng Cai*, Cardiac Sca-1+ Cells Are Not Intrinsic Stem Cells for Myocardial Development, Renewal, and Repair. Circulation, 2018, 138(25): 2919-2930.
(8) Diana Guallar, Xianju Bi, Jose Angel Pardavila, Xin Huang, Carmen Saenz, Xianle Shi, Hongwei Zhou, Francesco Faiola, Junjun Ding, Phensinee Haruehanroengra, Fan Yang, Dan Li, Carlos Sanchez-Priego, Arven Saunders, Feng Pan, Victor Julian Valdes, Kevin Kelley, Miguel G. Blanco, Lingyi Chen, Huayan Wang, Jia Sheng, Mingjiang Xu, Miguel Fidalgo, Xiaohua Shen, Jianlong Wang*, RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells, Nature genetics, 2018, 50(3): 443–451.
(9) Xin Huang, Sophie Balmer, Fan Yang, Miguel Fidalgo, Dan Li, Diana Guallar, Anna- Katerina Hadjantonakis*, Jianlong Wang*, Zfp281 is essential for epiblast maturation through transcriptional control of Nodal Signaling in the mouse embryo. Elife, 6 (2017): e33333.
(10) Saunders, A., D. Li, F. Faiola, X. Huang, M. Fidalgo, D. Guallar, J. Ding, F. Yang, Y. Xu, H. Zhou, J. Wang*. Context-dependent functions of nanog phosphorylation in pluripotency and reprogramming. Stem Cell Reports, 2017. 8(5): p. 1115-1123.
五、科研项目
西北农林科技大学引进人才科研启动经费:100万;主持
六、获奖情况
2015/12:博士研究生国家奖学金
七、联系方式
通讯地址:陕西杨凌邰城路3号西北农林科技大学 南校区科研楼2303B办公室
邮编: 712100
电子邮箱: fan.yang@nwafu.edu.cn
联系电话:029-87080069/15182316397