张继文
基本信息
张继文,男,1976年生于山东省滕州市。
1999年7月毕业于兰州大学化学化工学院获理学学士学位。
2005年6月,2013年6月分别获西北农林科技大学植物保护学院农药学硕士、博士学位。
2003年8-12月在中科院上海有机所周维善院士课题组学习。
2006年3-9月在维也纳大学化学系Mulzer课题组学习。
2014年12月-2015年3月在维也纳大学药学系Haider课题组学习。
工作经历
1999年7月至今在西北农林科技大学理学院工作。
1999年12月起任助教,2004年12月起任讲师,2009年12月起任副教授,2015年1月起任教授。2010年起任硕士生指导教师,2015年起任博士生导师。
荣誉获奖
2020年度陕西省优秀药学科技工作者
科学研究
1.国家自然科学基金面上项目,67万元,磺酰胺类新型杀虫活性化合物的设计合成、构效关系及靶标垂钓研究,项目编号:21977083,起止年限:2020.01-2023.12;
2.国家自然科学基金面上项目,80万元,作用于V-ATP酶的新型二氢沉香呋喃倍半萜杀虫剂的设计、合成与构效关系,项目编号:21372185,起止年限:2014. 01-2017.12;
3.国家自然科学基金青年项目,20万元,杀虫活性二氢沉香呋喃倍半萜结构优化研究,项目编号:30800729,起止年限:2009. 01-2011.12;
4.西北农林科技大学2009青年学术骨干支持计划,20万元,天然产物农药,项目编号:QNGG-2009-020,起止年限:2009.12-2012.12.
研究领域
(1)具有重要生物活性天然产物的化学与化学生物学
(2)农用化学品化学
科研成果转化
基于百合科竹根七属植物——散斑竹根七,开发出对瓜类白粉病具有高效铲除作用的植物源农药,相关技术成功转让,技术转让费为300万元。
近期发表论文
(1)Wangyu Zhao, Chaofu Yang_, Lijuan Han, Bo Zhou, Aijuan Li,Lulu Liu, Ziwei Zhang, Ziyu Wang, Wenjun Wu and Jiwen Zhang*,Design, synthesis, and insecticidal activities of propargyloxy-naphthalene-sulfonamide derivatives,Journal of Asian Natural Products Research, 2021,
(2)Li Aijuan,Chu Qianqian,Zhou Huifang,Yang Zhipeng,Liu Bo*,Zhang Jiwen*,Effective nitenpyram detection in a dual-walled nitrogen-rich In(III)/Tb(III)-organic framework,Inorganic Chemistry Frontiers,2021,
(8) Shaojun Zheng*, Rui Zhu, Bing Tang, Lizhuang Chen, Hongjin Bai*, Ji-wen Zhang*,Synthesis and biological evaluations of a series of calycanthaceous analogues as antifungal agents. Natural Product Research,2021,35(11),1816-1824
(3)Rui Zhu, Rui Guo, Ke Han, Wenying Xi, Shaojun Zheng, and Jiwen Zhang, Synthesis and Antimicrobial Characterization of Luotonin Derivatives, Natural Product Communications, 2020,15 (12) ,1-6
(4)Fangli Gang, Xiaoting Li, Chaofu Yang, Lijuan Han, Hao Qian, Shaopeng Wei, Wenjun Wu, Jiwen Zhang* Synthesis and Insecticidal Activity Evaluation of Virtually Screened Phenylsulfonamides J. Agric. Food Chem. 2020, 68, 11665−11671
(5)Chaofu Yang, Yan Feng, Xu Yang, Mingxia Sun, Zhenwang Li, Xuan Liu, Liang Lu,Xianyu Sun, Jiwen Zhang⁎, Xinhua He⁎,Synthesis and evaluation of 4-(1,3,4-oxadiazol-2-yl)-benzenesulfonamides as potent carbonic anhydrase inhibitors,Bioorganic & Medicinal Chemistry Letters 30 (2020) 126874
(6)Fang-li Gang, Feng Zhu, Chao-fu Yang, Xiao-ting Li, Ming-xia Sun, Hua Yang
Wen-jun Wu and Ji-wen Zhang*,Natural antifungal agents and neuritogenic ester from Disporopsis aspersa ,Natural Product Research,2020, 34(11), 1521–1527
(7)Shaojun Zheng*,Rui Zhu,Xinping Zhou,Lizhuang Chen,Hongjin Bai* and Ji-wen Zhang*,Synthesis and biological evaluation of calycanthaceous alkaloid analogs. Bioorganic & Medicinal Chemistry 27 (2019) 115088
(8)Xin Xi, Jielu Wei, Ximei Zhao, Feng Zhu, Zhan Hu, Wenjun Wu, Jiwen Zhang,
Synthesis of β-Dihydroagarofuran Derivatives and Preliminary Research on Their Insecticidal Activity. Chemistry of Natural Compounds, 2019, 55 (6), 1062–1066
(7) Fangli Gang, Hao Yan, Chunyang Ma, Le Jiang, Yingying Gu, Ziyu Liu, Lingyun Zhao, Xiumei Wang, Jiwen Zhang* and Xiaodan Sun*. Robust magnetic double-network hydrogels with self-healing, MR imaging, cytocompatibility and 3D printability. Chem. Commun., 2019, 55, 9801-9804
(9)Feng Zhu, Baojun Shi, Yong Li, Hua Yang, Shengnan Sun, Shuping Yao, Xianqinag Yin,* and Jiwen Zhang*. Chemical Constituents of Extracellular Extract of Haematococcus pluvialis. Chemistry of Natural Compounds, 2019, 55 (3), 578-579
(10)Chaofu Yang, Xiaoting Li, Jielu Wei, Feng Zhu, Fangli Gang, Shaopeng Wei, Yunlong Zhao, Ji-wen Zhang*, Wenjun Wu⁎, Synthesis and insecticidal activity in vitro and vivo of novel benzenesulfonyl derivatives based on potent target subunit H of V-ATPase Bioorganic & Medicinal Chemistry Letters 28 (2018) 3164–3167
(11)Fang-li Gang, Feng Zhu, Xiao-ting Li, Jie-lu Wei, Wen-jun Wu, and Ji-wen Zhang*,Synthesis and bioactivities evaluation of L-pyroglutamic acid analogues from natural product lead,Bioorganic & Medicinal Chemistry 26 (2018) 4644–4649
(12)Feng Zhu,Chengshan Yuan, Fangli Gang, Chaofu Yang, Wenjun Wu*, Jiwen Zhang*,Bioassay-guided isolation of antifungal compounds from Disporopsis aspera Engl. against Pseudoperonospora cubensis and Phytophthora infestans,Chemistry & Biodiversity, 2018, 15, e1800090
(13)Xin Xi, Ximei Zhao, Feng Zhu, Jielu Wei, Zhan Hu, Wenjun Wu and Jiwen Zhang*,Synthesis and Insecticidal Activity of β-Dihydroagarofuran Acetal Derivatives, Natural Product Communications, 2018,13 (4) ,395-398
(14)Shaojun Zheng, * Yongdong Gu, Rui Zhu, Longbo Li, Hongjin Bai,* and Jiwen Zhang*,Synthesis and antibacterial activity of calycanthaceous alkaloid derivatives Chemistry of Natural Compounds, 2018, 54 (1), 1-4