陈红英

陈红英，博士

女，博士，教授。1988-1992年，中国农业大学动物生理学与生物化学专业本科；1992-1998年，中国农业大学动物生理学与生物化学专业硕博连读；1998-2000年，中国科学院发育生物学研究所，博士后；2000-2009年，英国雷丁大学（University of Reading），Research fellow。2009年9月到西北农林科技大学生命科学学院工作，入选2009年教育部新世纪优秀人才支持计划。

研究方向

动物病毒-宿主互作关系，病毒蛋白的结构功能，杆状病毒表达系统

发表论文

发表科研论文40余篇。近五年通讯作者论文：

1. Xiaoyue Zhang, Kaixia Zhao, Lan Lan, Na Shi,| Hao Nan, Yanan Shi, Xiaodong Xu*, Hongying Chen*. Improvement of protein production by engineering a novel antiapoptotic baculovirus vector to suppress the expression of Sf-caspase-1 and Tn-caspase-1. Biotechnol Bioeng. 2021;May 15. doi: 10.1002/bit.27807

2. Yanfei Jiang, Hao Nan, Na Shi, Wenfang Hao, Juane Dong*, Hongying Chen*. Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis. Molecular Biology Reports. 2021 Mar; 48(3):2351-2364. doi: 10.1007/s11033-021-06267-3.

3. Cao Z, Liu S, Nan H, Zhao K, Xu X, Wang G, Ji H, Chen H*. Immersion immunization with recombinant baculoviruses displaying cyprinid herpesvirus 2 membrane proteins induced protective immunity in gibel carp. Fish Shellfish Immunol. 2019 Aug 14;93:879-887. doi: 10.1016/j.fsi.2019.08.036

4. Wang L, Zhang L, Huang B, Li K, Hou G, Zhao Q, Wu C, Nan Y, Du T, Mu Y, Lan J, Chen H*, Zhou EM*. A Nanobody Targeting Viral Non-Structural Protein 9 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication. J Virol. 2019 Feb 5, 93(4): e01888~18. doi: 10.1128/JVI.01888-18

5. Nan H, Lan J, Tian M, Dong S,Tian J, Liu L, Xu X and Chen H* (2018) The Network of Interactions Among Porcine Reproductive and Respiratory Syndrome Virus Non-structural Proteins. Front. Microbiol. 9:970.

6. Xiaoyue Zhang, Keyan Xu, Yanmei Ou, Xiaodong Xu* and Hongying Chen* Development of a baculovirus vector carrying a small hairpin RNA for suppression of sf-caspase-1 expression and improvement of recombinant protein production. BMC Biotechnology (2018) 18:24

7. Chen J, Xu X, Tao H, Li Y, Nan H, Wang Y, Tian M, Chen H*. (2017) Structural Analysis of Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 7α (NSP7α) and Identification of its Interaction with NSP9. Front. Microbiol., 8:853.

8. Chen J, Xu X, Tao H, Wang Y, Chen H*. (2016) Chemical shift assignments of nsp7α from porcine reproductive and respiratory syndrome virus. Biomol NMR Assign., 10(2):391-394.

9. Dong S, Liu L, Wu W, Armstrong SD, Xia D, Nan H, Hiscox JA, Chen H* Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for virus replication. Journal of Proteomics 2016, 146: 58–69 .

10. Liu L, Tian J, Nan H, Tian M, Li Y, Xu X, Huang B, Zhou E, Hiscox JA, Chen H*. Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein Interacts with Nsp9 and Cellular DHX9 to Regulate Viral RNA Synthesis. J Virol. 2016, 90:5384–5398.

专利

陈红英，许晓东，杨雄 一种识别HIV-1受体结合表位的可溶性单链抗体的制备方法，专利号：ZL 2013 1 0088900.1。

一种新型杆状病毒表达载体，申请号：201910650551.5

一种展示cyhv-2膜蛋白的重组杆状病毒及其制备方法和应用，申请号：201910724103.5

一种展示cyhv-2膜蛋白的重组杆状病毒及其制备方法和应用，申请号：201910724104.X

联系方式

单位：西北农林科技大学生命学院

地址： 陕西杨凌西农路22号，712100

电子邮件：chenhy@nwsuaf.edu.cn